DETERMINATION OF TREATMENT TIME AND EFFICACY WITH OXYGEN IN EXPERIMENTAL METHEMOGLOBINEMIA MODEL

Introduction: Methemoglobin, an abnormal form of hemoglobin, is one the causes that should be considered primarily in severe central cyanosis. Methylene blue and ascorbic acid are used as first-line therapies methemoglobinemia. Experience with use oxygen therapy not sufficient to conclude duration therapy. The aim present study find out effects on drug or toxic agent-induced Material Method: First group rats (n=6) were administered 100 mg/kg prilocaine intraperitoneally, kept at room temperature. second 100% 10 liters/min. All observed for 180 minutes, blood gas biochemical analyses performed end experiment period. Results: Fifty percent air (n=3) died spontaneously trial period, while all survived When evaluated terms survival, a statistical difference was found between groups (p <0.05). In addition, although there significant saturation levels <0.05), no increase partial arterial pressure, primary determinant oxygenation. Conclusion: This revealed suitable this type experimental study. Prilocaine doses did cause high methemoglobinemia due mortality, so goal target could met. It has been concluded can serve guide choosing methodologies employed planned future investigations topic.